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presentation.tex

@@ -137,43 +137,39 @@
   \thispagestyle{empty}
 \end{frame}
 
-
 \begin{frame}
   \begin{figure}
     \includegraphics[width=.8\textwidth]{Images/article.png}
   \end{figure}
-  \blfootnote{April 25, 2023}
+  \vfill
+  \tiny April 25, 2023
 \end{frame}
 
-\begin{frame}{CTCF}
+\begin{frame}{CTCF et structure chromatinienne}
   \begin{columns} 
     % Column 1
     \begin{column}{.30\textwidth}
       \begin{center}
-        \includegraphics[width=\textwidth]{Images/Ctcf_hoxa_tad.png}
+        \includegraphics[width=\textwidth]{Images/Ctcf_hoxa_tad.png}\\
+        \tiny CTCF binding sites in HoxA locus (Dixon et al., 2012)
       \end{center}
     \end{column}
     % Column 2
     \begin{column}{.33\textwidth}
       \begin{center}
-        \includegraphics[width=\textwidth]{Images/Chrom_HIC_boucles.png}
+        \includegraphics[width=\textwidth]{Images/Chrom_HIC_boucles.png}\\
+        \tiny Chromatin looping in Hi-C maps (Rao et al., 2014)
       \end{center}
     \end{column}
     % Column 3
     \begin{column}{.36\textwidth}
       \begin{center}
-        \includegraphics[width=.9\textwidth]{Images/Boucle_ctcf.png}
+        \includegraphics[width=.9\textwidth]{Images/Boucle_ctcf.png}\\
+        \tiny CTCF-mediated chromatin loops (Sanborn et al., 2015)
       \end{center}
     \end{column}
   \end{columns}
-
-  \blfootnote{
-  \begin{itemize}
-    \item[-] Dixon Jesse R et al. “Topological domains in mammalian genomes identified by analysis of chromatin interactions.” Nature vol. 485,7398 376-80. 11 Apr. 2012, doi:10.1038/nature11082
-    \item[-] Rao, Suhas S P et al. “A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.” Cell vol. 159,7 (2014): 1665-80. doi:10.1016/j.cell.2014.11.021
-    \item[-] Sanborn, Adrian L et al. “Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes.” Proceedings of the National Academy of Sciences of the United States of America vol. 112,47 (2015): E6456-65. doi:10.1073/pnas.1518552112
-  \end{itemize}
-  }
+  
 \end{frame}
 
 \begin{frame}{CTCF et oncogenèse}
@@ -224,18 +220,11 @@
   \blfootnote{Liu, Yu et al. “The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.” Nature genetics vol. 49,8 (2017): 1211-1218. doi:10.1038/ng.3909}
 \end{frame}
 
-\begin{frame}{\emoji{test-tube} Matériel}
-  \begin{itemize}
-    \item 181 LAL-T pédiatriques 
-    \item CGH-array / MLPA CTCF / ChIP CTCF / Methylation-array / Expression-array 
-  \end{itemize}
-\end{frame}
-
 \begin{frame}{\emoji{microscope} Résultats --- Observations}
   
   \begin{itemize}
     \item[{\large \ding{43}}] \alert{CGH} 8\% (n = 7/92) la zone minimale observées des délétions 16q inclus les exons 1 à 4 de \textit{CTCF}.
-    \item[{\large \ding{43}}] \alert{MLPA} 9\% (n = 18) des cas présentent une délétion hétérozygote de \textit{CTCF}.
+    \item[{\large \ding{43}}] \alert{MLPA} 9\% (n = 18/181) des cas présentent une délétion hétérozygote de \textit{CTCF}.
   \end{itemize}
   
   \vspace{1.5cm}